api 29 2011
1 de MAYO en Erandio
Asteburu honetan Erandion ekitaldi interesgarria
A lo largo del sábado y el domingo tenemos en varios barrios, actuaciones para preparar el Euskal Herriko Dantzari Eguna que se celebra en La Campa Erandio, a partir de las 11:30.
Estas dos últimas semanas en los comercios de Astrabudua y Altzaga podemos observar trajes y elementos para la danza, como prólogo de la actuación el sábado de los txikis en Astrabudua a partir de las 11:30 y a las 20:30 en el antiguo mercao de Altzaga, con todos los grupos del municipio.
La verdad es que no es la mejor fecha porque este año mas que nunca el 1 de mayo, los trabajadores y trabajadoras tenemos una cita para manifestarnos en Bilbao a las 11:30 contra todos los recortes que estamos sufriendo, además a las 10:30 tenemos una rueda de prensa de Bildu en apoyo a la clase trabajadora.
Bueno como siempre tenemos opciones para todos los gustos.
En la página de Erandioko Agenda hemos publicado el calendario y horario del Euskal Herriko Dantzari Eguna.
Los datos los hemos extraido de la web de Bizkaiako Dantzari Eguna que hemos accedido gracias a las publicaciones del facebook de Santi Neira (Concejal de Cultura de Erandio) y del blog de Erandio.
Etiquetas todos los blogs: bildu ; dantzari eguna ; ea ; Erandio ;
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CJC 1295 Ipamorelin Enhance Your Wellness Today
CJC 1295 Ipamorelin: The Ultimate Guide to Peptide
Therapy for Muscle Growth, Fat Loss, and Anti‑Aging
Peptide therapy has gained popularity among fitness enthusiasts, bodybuilders,
and those seeking longevity solutions. At the heart of
many protocols is CJC 1295 combined with Ipamorelin—a duo
that stimulates growth hormone release while minimizing side effects associated with older
analogues. This guide explores how these peptides work, their therapeutic benefits, practical treatment options at reputable centers, and essential
safety considerations.
—
CJC 1295 Ipamorelin Treatment at Physicians Rejuvenation Centers
Physicians Rejuvenation Centers specialize in evidence‑based peptide protocols tailored to individual goals.
Their approach typically includes:
Initial Consultation: Comprehensive health assessment, hormone panel,
and discussion of objectives (muscle hypertrophy, fat reduction, anti‑aging).
Customized Dosage Plan: Adjusted based on age, weight, baseline growth hormone levels, and
desired outcomes.
Administration Methods: Subcutaneous injections administered by trained staff or patient self‑injectable kits with clear instructions.
Monitoring & Follow‑Up: Regular blood work to track growth hormone,
IGF‑1, insulin sensitivity, and lipid profile. Adjustments are made as needed.
Supportive Lifestyle Guidance: Nutrition plans, resistance training protocols, sleep hygiene, and stress management to maximize peptide efficacy.
Patients report increased energy, improved muscle tone, faster recovery times, and a noticeable reduction in body fat after consistent treatment
courses ranging from 8 to 12 weeks.
Understanding CJC 1295 Ipamorelin
CJC 1295 is a growth hormone‑releasing hormone
(GHRH) analogue that prolongs the natural release of growth
hormone. Ipamorelin, a selective growth hormone secretagogue, complements this by stimulating the pituitary to release GH
without significant prolactin or cortisol elevation. Together,
they create a synergistic effect:
Sustained GH Secretion: CJC 1295’s long‑acting profile keeps GH levels elevated for extended periods.
Targeted Stimulation: Ipamorelin ensures that
GH pulses are efficient and tailored to the body’s needs.
Balanced Hormonal Profile: Minimal interference with other endocrine
axes, preserving overall hormonal harmony.
Definition of Peptides and Their Role in the Body
Peptides are short chains of amino acids linked by peptide bonds.
They function as:
Hormones (e.g., insulin, glucagon).
Neurotransmitters (e.g., endorphins).
Growth Factors (e.g., IGF‑1).
Immune Modulators (e.g., antimicrobial peptides).
In therapeutic contexts, synthetic peptides mimic or enhance natural signals to promote tissue repair, metabolic
regulation, and cellular communication. Because of their specificity, peptides can target precise receptors with fewer
off‑target effects compared to traditional drugs.
Mechanism of Action of CJC 1295
CJC 1295 binds to the GHRH receptor on pituitary somatotroph cells,
mimicking endogenous growth hormone‑releasing hormone. Its pegylated
structure:
Extends Half‑Life: Allows once‑daily or even less frequent
dosing.
Enhances Receptor Affinity: Leads to robust GH
release with lower peptide amounts.
Stimulates IGF‑1 Production: In liver and peripheral tissues,
driving anabolic processes.
The result is a cascade that boosts protein synthesis, improves
lipid metabolism, and supports cellular regeneration.
Benefits of CJC 1295 Ipamorelin
Muscle Growth & Strength
- Increased protein synthesis.
- Enhanced satellite cell activation.
- Faster recovery from intense workouts.
Fat Loss & Metabolic Health
- Elevated basal metabolic rate.
- Improved insulin sensitivity.
- Reduction in visceral fat deposition.
Anti‑Aging Effects
- Skin elasticity and collagen production.
- Bone density support.
- Cognitive function preservation through neuroprotective pathways.
Reduced Side Effects Compared to Older Analogues
- Minimal prolactin surge, lowering the risk of
gynecomastia or lactation.
- Low cortisol response, reducing stress‑related side effects.
- Mild appetite changes, making dietary adherence easier.
—
Safety and Considerations for CJC 1295 Ipamorelin Use
Dosage Precision: Over‑dosing can lead to water retention, joint pain, or glucose intolerance.
Strict adherence to prescribed protocols is essential.
Injection Site Care: Rotate sites to prevent lipodystrophy; monitor
for local inflammation.
Long‑Term Monitoring: Periodic hormone panels ensure GH and IGF‑1
remain within therapeutic ranges.
Contraindications: Individuals with active cancers,
uncontrolled diabetes, or pituitary disorders should
avoid therapy unless supervised by an endocrinologist.
Potential Interactions: Concurrent use of steroids or other anabolic agents may amplify side effects;
discuss all supplements with a healthcare provider.
Importance of Consulting With a Medical Professional
Peptide therapy is not a self‑administered supplement.
A qualified clinician:
Assesses Baseline Health: Identifies contraindications and baseline hormone levels.
Designs Personalized Regimens: Balances efficacy with safety for each patient’s profile.
Monitors Progress & Adjusts Doses: Prevents over‑exposure or under‑dosing.
Provides Comprehensive Support: Integrates nutrition, exercise, and lifestyle interventions.
Self‑prescribing can lead to misuse, counterfeit
products, and serious health risks. Professional guidance ensures that the therapeutic benefits are realized while minimizing potential harms.
Related Therapies
Patients often combine cjc ipamorelin side effects reddit 1295 Ipamorelin with complementary
treatments:
SARMs (Selective Androgen Receptor Modulators): For additional muscle hypertrophy.
Nutraceuticals: Creatine, BCAAs, and omega‑3 fatty acids
support anabolic processes.
Lifestyle Interventions: Structured resistance training, adequate sleep, and stress
reduction amplify peptide effects.
Other Peptide Protocols: Sermorelin or growth hormone secretagogues can be incorporated for varied therapeutic goals.
Send an Inquiry
For personalized guidance on CJC 1295 Ipamorelin therapy, consult with a certified peptide specialist at Physicians Rejuvenation Centers.
Their team is ready to evaluate your health status and design a
tailored protocol that aligns with your wellness
objectives.
Oxandrolone Wikipedia
**Bromazepam**
| | |
|—|—|
| **Generic name(s)** | Bromazepam |
| **Brand names** | Lexotan, Lexan, Lexon, Lexi, Brontal, BROM,
etc. |
| **Class** | Benzodiazepine – anxiolytic / sedative
|
| **Indications** | • Generalized anxiety disorder
• Panic disorders (with or without agoraphobia)
• Short‑term relief of severe agitation or insomnia related
to anxiety |
| **Contraindications** | • Severe respiratory insufficiency, hepatic failure, or renal failure with poor clearance;
• Pregnancy (category D) and lactation – use only if benefits outweigh risks;
• Known hypersensitivity to benzodiazepines |
| **Side‑effects / adverse events** | • Somnolence, dizziness, impaired
coordination
• Cognitive dulling, memory impairment (especially with long‑term use)
• Paradoxical agitation or aggression in some patients (particularly children and elderly)
• Dependence & withdrawal syndrome on prolonged therapy |
| **Precautions / warnings** | • Monitor for sedation and respiratory depression;
• Use lowest effective dose, especially in the elderly and
those with hepatic impairment
• Avoid concomitant use of CNS depressants (opioids, alcohol) that
increase risk of respiratory arrest |
| **Drug interactions** | • Alcohol – additive CNS depression, ↑sedation, ↑liver
toxicity
• Opioids – increased sedation, respiratory depression; may potentiate withdrawal symptoms when used together or sequentially
• Other benzodiazepines/benzodiazepine‑like agents – additive CNS depressant effects |
| **Side effect profile** | • Common: drowsiness, dizziness, impaired coordination, confusion (especially in the elderly), memory
impairment, blurred vision, hypotension
• Less common: paradoxical agitation or aggression, nausea,
headache, dry mouth, increased appetite, constipation,
urinary retention, bradycardia or tachycardia, hypersensitivity
reactions |
**Key points for clinical practice**
- **Monitor for additive CNS depression** when alcohol is consumed
while a patient is taking diazepam; advise patients to
avoid drinking.
- **Assess for cognitive and psychomotor impairment** before prescribing diazepam for tasks requiring alertness (e.g., driving, operating machinery).
- **Be vigilant about paradoxical reactions**, especially in the elderly or
those with psychiatric comorbidities.
- **Use the lowest effective dose for the shortest duration** to mitigate
the risk of tolerance and dependence.
—
### 1.2 How is diazepam metabolized in the liver?
What are its metabolites? Which enzyme is involved?
Diazepam undergoes extensive hepatic metabolism via cytochrome P450 enzymes.
- **Primary oxidative metabolism:** CYP3A4 (major)
→ N-demethylation → *n*-desmethyldiazepam (also known as nordazepam).
- **Nordazepam** is further metabolized to oxazepam and
temazepam via a second oxidation step by CYP2C19/CYP3A4.
- **Secondary pathway:** CYP2C19 can also produce *α*-hydroxybenzodiazepine metabolites (e.g.,
α-hydroxy-diazepam).
- **Additional minor products:** N-acetylation and glucuronidation of oxazepam
and temazepam by UGT enzymes, leading to conjugated excretion.
The half-lives differ: nordazepam (~7–10 days), oxazepam (~8–12 hours),
temazepam (~1.5–2 days). Thus, the longer-acting metabolites extend therapeutic activity but also risk accumulation with repeated dosing.
—
## 3. Pharmacodynamic Profile
| **Parameter** | **Value / Observation** |
|—————|————————|
| Receptor subtype | Primarily GABAA receptors (benzodiazepine binding site).
|
| Modulation | Positive allosteric modulator; increases
chloride influx, hyperpolarizing neurons. |
| Onset of action | 30–45 min for oral administration; peak plasma ~1–2 h.
|
| Duration of effect | 8–12 h (oral); longer with sustained-release formulation. |
| Tolerability | Mild sedation, ataxia, dizziness; rare paradoxical agitation in susceptible individuals.
|
| Withdrawal profile | Low risk of severe withdrawal; mild rebound anxiety or insomnia if discontinued abruptly after prolonged use.
|
—
## 4. Potential Side‑Effects
### Acute (within first 2 weeks)
| Symptom | Likelihood | Typical Dose | Notes |
|———|————|————–|——-|
| Mild sedation, sleepiness | Common | 15 mg/day | Avoid heavy machinery |
| Dizziness or vertigo | Occasional | Any dose |
Often resolves as tolerance develops |
| Nausea, vomiting | Uncommon | Any dose | Usually transient |
| Dry mouth | Mild | Any dose | Encourage hydration |
### Chronic (long‑term)
| Symptom | Likelihood | Typical Dose | Notes |
|———|————|————–|——-|
| Tolerance requiring higher doses | Moderate | >15 mg/day | Monitor for escalation; consider adjunctive
therapy |
| Physical dependence / withdrawal symptoms upon abrupt cessation | Low
| 5–10 mg/day | Discontinuation should be gradual if necessary |
| Cognitive slowing or memory impairment | Rare | Any dose | May
manifest in older adults; assess baseline cognition |
| Mood changes (e.g., depression, anxiety) | Rare |
Any dose | Monitor mood and provide counseling as needed |
**Note:** The above probabilities are illustrative estimates
based on limited case reports and general pharmacological principles.
Clinicians should rely on their judgment, patient monitoring, and
available evidence to guide therapy.
—
### 5. Implementation Checklist for Clinicians
| Step | Action | Notes |
|——|——–|——-|
| **1. Patient Selection** | - Confirm diagnosis (e.g., insomnia, anxiety).
- Verify that other pharmacologic options are unsuitable or have failed.
- Obtain informed consent discussing off‑label
use and limited evidence. | Document patient’s medical history, current medications, allergies.
|
| **2. Baseline Assessment** | - Record vital signs (BP, HR), weight, height.
- Assess sleep quality using standardized scales (PSQI, ESS).
- Evaluate mental status (PHQ‑9, GAD‑7). | Establish baseline for
monitoring changes and side effects. |
| **3. Dosage Initiation** | - Start with 1–2 mg
of oral oxycodone (controlled‑release) once daily.
- For immediate release formulations, use 5 mg dose if needed.
| Consider patient’s opioid tolerance; adjust accordingly.
|
| **4. Titration & Monitoring** | - Increase by 1 mg increments
every 3–5 days as tolerated and if symptoms persist.
- Max daily dose: Evaluate Patient History & Current Medications
|
|–> Is there any history of substance misuse or addiction?
|–Yes–> Avoid prescribing tramadol; consider alternative analgesics.
|–No–> Proceed to next step.
|
|–> Does the patient have severe liver disease (Child‑Pugh
B/C) or renal impairment (eGFR Consider non‑opioid alternatives; if
analgesia needed, use alternative opioids.
|–No–> Proceed to next step.
|
|–> Are there any drug interactions that could lead to serotonin syndrome or P450 inhibition?
|–Yes–> Avoid tramadol; consider other analgesics.
|–No–> Tramadol can be considered.
|
|–> Evaluate pain severity: mild‑moderate (tramadol appropriate) vs severe (other opioids).
“`
**Outcome:** Provide final recommendation or alternative plan.
Let’s craft the final answer accordingly. The user wants “step-by-step guide on how to decide whether a patient should receive Tramadol or not.” So we need to
produce such a guide, likely in bullet points or numbered steps
with sub-steps, maybe incorporate tables for quick decision making.
Also include considerations like:
- Contraindications: hypersensitivity, seizure disorder,
severe hepatic impairment, drug interactions (MAO inhibitors, SSRIs, SNRIs),
concurrent use of other drugs that prolong QT interval.
- Need to monitor for side effects: nausea, dizziness, sedation, constipation; potential for abuse clen and anavar cycle dosage dependence.
We can also provide a decision tree or flowchart.
Provide an example scenario.
Also mention guidelines such as those from American Pain Society, WHO
analgesic ladder, etc.
Thus, my answer should be thorough but concise enough to fit within chat.
Ok let’s produce the answer accordingly.## 1️⃣ Quick‑Start Guide (≤ 200 words)
| What you need | How to do it |
|—————|————–|
| **Indication** | Moderate‑to‑severe pain that is not
controlled by NSAIDs, acetaminophen, or weak opioids. Avoid if the patient has
uncontrolled hypertension, active GI bleeding, severe hepatic/renal failure, or a history of opioid abuse.
|
| **First‑Line Regimen** |
• **Morphine IV** 0.1 mg/kg every 4 h PRN (or 30 mg q6 h for adults).
• **Fentanyl IV** 2–5 µg every 4 h PRN (or 10 µg q6 h).
• **Hydromorphone IV** 0.2–0.3 mg every 4 h PRN.
|
| **Dosing Schedule** | 1. Give the drug
at the scheduled time.
2. If pain persists after 30–60 min, give a second dose (for
opioids) or consider a short‑acting nonopioid (e.g., IV ketorolac).
3. Reassess pain score; if still ≥4/10, give another
dose up to the maximum safe limit for that drug.
|
| **Monitoring** | • Vital signs before each dose
(BP, HR, RR, SpO₂).
• Pain score (0–10) before and after each dose.
• Watch for respiratory depression, hypotension,
sedation.
• Record all doses in the patient’s medication chart.
|
| **Documentation** | • Time of administration.
• Dose given.
• Pain score pre‑ and post‑dose.
• Any adverse reactions noted.
• Nursing signature. |
—
### 4. Adverse Events / Reactions
- **Respiratory depression** (slow/absent breathing) → immediate cessation of opioid, call for
assistance.
- **Severe hypotension** → stop medication, give fluid bolus, monitor vitals.
- **Allergic reaction** (rash, swelling, difficulty breathing) → discontinue drug, treat with antihistamine/epinephrine if necessary.
—
### 5. Summary
1. **Pre‑medication assessment** – vital signs, pain score, sedation scale, allergies,
contraindications.
2. **Choose an opioid** (fentanyl or morphine) based on patient factors; calculate dose using standard conversion tables.
3. **Administer** per protocol, monitor for efficacy and adverse effects.
4. **Document** everything: vitals, pain score, medication given,
response, side‑effects.
Follow your local anesthesia service’s detailed protocols for exact dosing formulas, weight‑based calculations, and monitoring intervals to ensure safe, effective analgesia during the
intraoperative period.
The journey through a test‑primobolan (anavar) cycle is
one that many bodybuilders and fitness enthusiasts consider when they are
looking for a lean, natural‑looking physique while minimizing
the harsh side effects often associated with other
anabolic steroids. This guide provides an in‑depth look at what happens during such a cycle, how to prepare for competition, and what you can realistically expect from both Primo Steroid and its combination with test.
—
Primobolan Steroid Review: Decoding Primo Steroid for Bodybuilding
Primobolan, also known by its chemical name methenolone acetate or methenolone enanthate depending on the ester used,
is one of the most popular anabolic steroids in the bodybuilding community
because of its mild nature and relative safety profile.
The drug has a low androgenic rating compared to many other steroids, which
means it tends not to cause as much water retention, oiliness, or gynecomastia (development of breast tissue)
when used at typical bodybuilding doses.
Key attributes of Primobolan:
Low androgenicity: Allows users to avoid the hormonal side effects that are common with
more potent steroids such as testosterone enanthate or stanozolol.
High anabolic potential: Supports lean muscle growth and
helps preserve muscle during cutting phases.
Minimal estrogenic conversion: Unlike many other anabolic agents, Primobolan does not convert into estrogen in significant amounts, reducing the risk of water retention and bloating.
Short half‑life (when acetate): The acetate ester has
a relatively short half‑life (~3–5 days), which means
blood levels drop quickly after each injection. Users often prefer the enanthate form for longer lasting effects but this is less common in cutting cycles.
Because of these characteristics, many athletes use Primobolan as part of a “lean cycle” or a final phase before a competition to
sharpen definition while preserving muscle mass.
What is Primo Steroid?
Primo Steroid refers to the commercial product that contains
methenolone acetate. It can be found in various formulations – typically a powder for injection, sometimes with a small vial of propylene glycol and other additives for proper dissolution.
The name “Primo” itself is simply a brand identifier; the active ingredient remains the same regardless of manufacturer.
Dosage guidelines:
Cycle length: 4–6 weeks
Typical dose range: 50–100 mg per injection, usually
administered twice a week (for acetate) or once a week (for enanthate).
Injection sites: Deltoid (upper arm), gluteal muscles (buttocks), and sometimes the thigh.
Primo Steroid is often combined with testosterone to counterbalance
the low androgenic profile of methenolone. Testosterone provides an anabolic base, while Primobolan refines the lean look without adding significant water retention.
Pre‑Competition Preparations
Preparing for a bodybuilding competition while on a test/primobolan cycle involves a meticulous
plan that balances nutrition, training, supplementation, and timing.
Here’s a step‑by‑step guide:
Nutrition:
- Caloric deficit: Reduce calories by 500–700 per day to shed
body fat while preserving muscle.
- Macronutrient split: Aim for ~30 % protein, 40 % carbohydrates
(mostly complex), and 30 % healthy fats.
- Hydration management: Increase water intake during the first half of the cycle; taper
down in the last week to avoid bloating.
Training:
- Hypertrophy focus early on: Continue heavy weight training with moderate volume
to keep muscle mass intact.
- Cutting phase: Shift toward higher rep ranges (12–20)
and incorporate cardio sessions 4–5 times a week.
- Pre‑stage work: In the final 2 weeks, reduce overall intensity but maintain stimulus for each muscle group.
Supplements:
- Protein powder to hit daily protein targets.
- Branched‑chain amino acids (BCAAs) during workouts to aid recovery.
- Omega‑3 fatty acids and a multivitamin for overall health.
- Liver support if you are using any other steroids or supplements
that may stress the liver.
Cycle Timing:
- Week 1–2: Begin test (e.g., testosterone enanthate) at 200 mg
per week, inject Primobolan acetate twice a week.
- Week 3–5: Increase test dose to 250–300 mg per week;
maintain primobolan at the same level. Monitor for any side
effects such as acne or water retention.
- Week 6: Start tapering both compounds: reduce testosterone by
50 % and stop Primobolan after a few days.
- Post‑cycle therapy (PCT): Begin an aromatase inhibitor or selective estrogen receptor modulator
(SERM) within 2–3 days of the last injection to
help restore natural hormone production.
Monitoring:
- Weekly weigh‑ins: Track weight changes to ensure you are losing fat, not muscle.
- Body composition scans (if available): Measure lean mass vs.
body fat percentage.
- Blood tests: Check liver enzymes, lipid profile, and testosterone levels if possible.
—
Expected Results
A properly managed test/primobolan cycle can produce noticeable
changes in a short period:
Lean muscle retention: Users often report keeping the bulk they built earlier in their
training while reducing overall mass.
Enhanced definition: Primobolan’s low water retention helps muscles appear more defined and ripped, which is
ideal for stage presentation.
Reduced fat levels: The anabolic support from testosterone combined with a
caloric deficit leads to efficient fat loss.
It is important to note that results vary significantly based on genetics, diet, training intensity,
and adherence to the cycle plan. Some athletes experience subtle changes while others see dramatic improvements in muscle tone and definition.
Conclusion
A test‑primobolan (anavar) cycle is a strategic choice for bodybuilders who want to preserve muscle mass while cutting down fat and achieving a cleaner look before competition. Primo Steroid, with its low androgenic profile, serves as an excellent companion to testosterone, allowing athletes to maintain an anabolic environment without excessive water retention or estrogen conversion. With
careful planning—nutritional discipline, targeted training,
proper dosing, and vigilant monitoring—competitors can maximize the
benefits of this steroid combination while minimizing risks.
References:
womens
anabolic steroids online
References:
autovin-info.com
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